Back to search

Article

Baseline and treatment-emergent bedaquiline resistance in drug-resistant tuberculosis: A systematic review and meta-analysis

2023-08-07

Abstract excerpt

<h4>Rationale</h4> Bedaquiline is a novel antimycobacterial agent for drug-resistant tuberculosis (DR-TB) and is classified as a World Health Organization (WHO) Group A drug due to its excellent clinical efficacy, high bactericidal activity, and potent sterilizing effect. Baseline and treatment-emergent bedaquiline resistance have been described but prevalence and incidence have not been reported, leading to gaps...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
0d9cc4e7-f5e8-5f0d-b97f-fadfb7bff31b
DOI
10.1101/2023.08.07.23293687
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Baseline and treatment-emergent bedaquiline resistance in drug-resistant tuberculosis: A systematic review and meta-analysisDOI 10.1101/2023.08.07.23293687
Genotype-Phenotype Characterization of Serial Mycobacterium tuberculosis Isolates in Bedaquiline-Resistant Tuberculosis.Semantic proximity
High frequency of bedaquiline resistance in programmatically treated drug-resistant TB patients with sustained culture-positivity in Cape Town, South AfricaSemantic proximity
We Are Underprepared for Bedaquiline Resistance: A Call for Clinical and Programmatic Readiness.Semantic proximity
Baseline and acquired resistance to bedaquiline, linezolid and pretomanid, and impact on treatment outcomes in four tuberculosis clinical trials containing pretomanidSemantic proximity
Detection of a historic reservoir of bedaquiline / clofazimine resistance associated variants in <i>Mycobacterium tuberculosis</i>Semantic proximity
Bedaquiline Resistance: Its Emergence, Mechanism, and PreventionSemantic proximity
Estimating the relative contribution of transmission to bedaquiline resistance burden in tuberculosis. A transmission threshold modelSemantic proximity
Global mapping of bedaquiline-resistant Mycobacterium tuberculosis: a systematic review.Semantic proximity
Widespread loss-of-function mutations implicating preexisting resistance to new or repurposed anti-tuberculosis drugsSemantic proximity
Assessment of epidemiological and genetic characteristics and clinical outcomes of resistance to bedaquiline in patients treated for rifampicin-resistant tuberculosis: a cross-sectional and longitudinal studySemantic proximity
Systematic review of mutations associated with resistance to the new and repurposed Mycobacterium tuberculosis drugs bedaquiline, clofazimine, linezolid, delamanid and pretomanid.Semantic proximity
Opportunities and limitations of genomics for diagnosing bedaquiline-resistant tuberculosis: an individual isolate meta-analysisSemantic proximity
Select a neighboring publication to make it the new centre.