Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Prevalence and extent of heteroresistance by next generation sequencing of multidrug-resistant tuberculosis.

PloS one - 1 Jan 2017

Operario Darwin J, Koeppel Alexander F, Turner Stephen D, Bao Yongde, Pholwat Suporn, Banu Sayera, Foongladda Suporn, Mpagama Stellah, Gratz Jean, Ogarkov Oleg, Zhadova Svetlana, Heysell Scott K, Houpt Eric R

Abstract excerpt

Amplicon-based Next Generation Sequencing (NGS) is an emerging method for Mycobacterium tuberculosis drug susceptibility testing (DST) but has not been well described. We examined 158 clinical multidrug-resistant M. tuberculosis isolates via NGS of 11 resistance-associated gene regions covering 3519 nucleotides. Across these gene regions, complete resistance or heteroresistance (defined as 1%-99% mutation) was...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to DST gene
Share to High-Throughput Nucleotide Sequencing

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Mutation

Share to Mycobacterium research and diagnosis

Share to Mycobacterium tuberculosis

Share to Phenotype

Share to Tuberculosis, Multidrug-Resistant

Share to Tuberculosis Research and Epidemiology

Source

Open in PubMed Open full text

Identifiers

PMID: 28545050
DOI: 10.1371/journal.pone.0176522
PMCID: PMC5436647

Genes

DST

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Prevalence and extent of heteroresistance by next generation sequencing of multidrug-resistant tuberculosis.PMID 28545050Read ↗

Application of next-generation sequencing to detect variants of drug-resistant Mycobacterium tuberculosis: genotype–phenotype correlationSemantic proximity Read ↗

High proportion of heteroresistance in gyrA and gyrB in fluoroquinolone-resistant Mycobacterium tuberculosis clinical isolates.Semantic proximity Read ↗

Direct detection of drug-resistant Mycobacterium tuberculosis using targeted next generation sequencingSemantic proximity Read ↗

Whole-genome sequencing reveals genotypic resistance in phenotypically susceptible Mycobacterium tuberculosis clinical isolates.Semantic proximity Read ↗

Mixed infections and heteroresistance of Mycobacterium tuberculosis among multidrug-resistant tuberculosis in China: a genomic epidemiology studySemantic proximity Read ↗

Lesion Heterogeneity and Long-Term Heteroresistance in Multidrug-Resistant Tuberculosis.Semantic proximity Read ↗

Mixed-strain infection and heteroresistance in drug-resistant tuberculosis: insights from a whole-genome sequencing pilotSemantic proximity Read ↗

Detection of a novel mutation in the rpoB gene in a multidrug resistant Mycobacterium tuberculosis isolate using whole genome next generation sequencing.Semantic proximity Read ↗

Predicting isoniazid resistance in Mycobacterium tuberculosis complex in New York State using whole-genome sequencing.Semantic proximity Read ↗

Application of Next Generation Sequencing for Diagnosis and Clinical Management of Drug-Resistant Tuberculosis: Updates on Recent Developments in the FieldSemantic proximity Read ↗

Characterization of Mycobacterium tuberculosis heteroresistance by genotyping.Semantic proximity Read ↗

Dissecting rifampicin heteroresistance in Mycobacterium tuberculosis: integrating whole-genome sequencing with phenotypic and clonal validation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.