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Article

Assessing MC1R Variants in Lentigo Maligna Melanoma within the Utah Population.

Cancer research communications - 1 Jul 2025

Jiang Amanda, Huntsman Annabelle, Becker Carly, Feng Bing-Jian, Marks Kayla, Donigan Jessica, Duffy Keith L, Frigerio Alice, Grossman Douglas, Neklason Deborah W, Judson-Torres Robert L, Deacon Dekker C

Abstract excerpt

Lentigo maligna (LM) and lentigo maligna melanoma (LMM) arise from chronically sun-damaged skin. LM/LMM incidence continues to increase, particularly in Utah, where melanoma rates are twice the national average. The melanocortin-1 receptor (MC1R) has been studied in melanocyte pigmentation and DNA repair but has yet to be thoroughly investigated in LM/LMM. We investigated allele and genotype frequencies of...

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Identifiers

PMID: 40673485
DOI: 10.1158/2767-9764.CRC-25-0263
PMCID: PMC12301710

Genes

MC1R

Provenance

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