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Article

Unique Features of Melanoma Risk and Diagnosis in Red-Haired Populations.

International journal of molecular sciences - 30 Aug 2026

Ebrahimi Kiran R, Ostrowski Stephen M, Fisher David E

Abstract excerpt

Cutaneous melanoma is the most lethal skin cancer, and risk is strongly shaped by pigmentary phenotype. The red-hair color phenotype, marked by red hair, fair skin, freckling, and poor tanning, carries elevated melanoma risk driven largely by loss-of-function variants in the melanocortin 1 receptor gene (MC1R). This risk is not explained by reduced ultraviolet protection alone. Impaired MC1R signaling shifts...

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Topics

Humans
Receptor, Melanocortin, Type 1
Melanoma
Skin Neoplasms
Hair Color
Melanins
Genetic Predisposition to Disease

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Phenotype

Source

Open in PubMed Open full text

Identifiers

PMID: 42737661
DOI: 10.3390/ijms27177765
PMCID: PMC13566574

Genes

MC1R

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 24 Oct 2026.

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