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Article

MC1R genotypes and risk of melanoma before age 40 years: a population-based case-control-family study.

International journal of cancer - 1 Aug 2012

Cust Anne E, Goumas Chris, Holland Elizabeth A, Agha-Hamilton Chantelle, Aitken Joanne F, Armstrong Bruce K, Giles Graham G, Kefford Richard F, Schmid Helen, Hopper John L, Mann Graham J, Jenkins Mark A

Abstract excerpt

The contribution of melanocortin-1 receptor (MC1R) gene variants to the development of early-onset melanoma is unknown. Using an Australian population-based, case-control-family study, we sequenced MC1R for 565 cases with invasive cutaneous melanoma diagnosed between ages 18 and 39 years, 409 unrelated controls and 518 sibling controls. Variants were classified a priori into "R" variants (D84E, R142H, R151C,...

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Identifiers

PMID: 22095472
DOI: 10.1002/ijc.27357
PMCID: PMC4330189

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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