Article
Histologic and Phenotypic Factors and MC1R Status Associated with BRAF(V600E), BRAF(V600K), and NRAS Mutations in a Community-Based Sample of 414 Cutaneous Melanomas.
The Journal of investigative dermatology - 1 Apr 2016
Hacker Elke, Olsen Catherine M, Kvaskoff Marina, Pandeya Nirmala, Yeo Abrey, Green Adèle C, Williamson Richard M, Triscott Joe, Wood Dominic, Mortimore Rohan, Hayward Nicholas K, Whiteman David C
Abstract excerpt
Cutaneous melanomas arise through causal pathways involving interplay between exposure to UV radiation and host factors, resulting in characteristic patterns of driver mutations in BRAF, NRAS, and other genes. To gain clearer insights into the factors contributing to somatic mutation genotypes in melanoma, we collected clinical and epidemiologic data, performed skin examinations, and collected saliva and tumor...
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