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Article

A large French case-control study emphasizes the role of rare Mc1R variants in melanoma risk.

BioMed research international - 1 Jan 2014

Hu Hui-Han, Benfodda Mériem, Dumaz Nicolas, Gazal Steven, Descamps Vincent, Bourillon Agnès, Basset-Seguin Nicole, Riffault Angélique, Ezzedine Khaled, Bagot Martine, Bensussan Armand, Saiag Philippe, Grandchamp Bernard, Soufir Nadem

Abstract excerpt

BACKGROUND: The MC1R gene implicated in melanogenesis and skin pigmentation is highly polymorphic. Several alleles are associated with red hair and fair skin phenotypes and contribute to melanoma risk. OBJECTIVE: This work aims to assess the effect of different classes of MC1R variants, notably rare variants, on melanoma risk. Methods. MC1R coding region was sequenced in 1131 melanoma patients and 869 healthy...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 24982914
DOI: 10.1155/2014/925716
PMCID: PMC4003837

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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