Article
Association of MC1R variants and host phenotypes with melanoma risk in CDKN2A mutation carriers: a GenoMEL study.
Journal of the National Cancer Institute - 20 Oct 2010
Demenais F, Mohamdi H, Chaudru V, Goldstein A M, Newton Bishop J A, Bishop D T, Kanetsky P A, Hayward N K, Gillanders E, Elder D E, Avril M F, Azizi E, van Belle P, Bergman W, Bianchi-Scarrà G, Bressac-de Paillerets B, Calista D, Carrera C, Hansson J, Harland M, Hogg D, Höiom V, Holland E A, Ingvar C, Landi M T, Lang J M, Mackie R M, Mann G J, Ming M E, Njauw C J, Olsson H, Palmer J, Pastorino L, Puig S, Randerson-Moor J, Stark M, Tsao H, Tucker M A, van der Velden P, Yang X R, Gruis N
Abstract excerpt
BACKGROUND: Carrying the cyclin-dependent kinase inhibitor 2A (CDKN2A) germline mutations is associated with a high risk for melanoma. Penetrance of CDKN2A mutations is modified by pigmentation characteristics, nevus phenotypes, and some variants of the melanocortin-1 receptor gene (MC1R), which...
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