Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A conserved coupling of transcriptional ON and OFF periods underlies bursting dynamics.

Nature structural & molecular biology - 1 Oct 2025

Chen Po-Ta, Levo Michal, Zoller Benjamin, Gregor Thomas

Abstract excerpt

Transcription commonly occurs in bursts, with alternating productive (ON) and quiescent (OFF) periods determining mRNA production rates. However, how bursting dynamics regulate transcription is not well understood. Here, we conduct real-time measurements of endogenous transcriptional bursting with single-mRNA sensitivity. Using the diverse transcriptional activities present in early Drosophila embryos, we find...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alleles
Share to Drosophila
Share to Drosophila melanogaster

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Drosophila Proteins

Share to Embryo, Nonmammalian

Share to Gene Expression Regulation, Developmental

Share to RNA, Messenger

Share to Transcription, Genetic

Source

Open in PubMed Open full text

Identifiers

PMID: 40664961
DOI: 10.1038/s41594-025-01615-4
PMCID: PMC13137155

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A conserved coupling of transcriptional ON and OFF periods underlies bursting dynamics.PMID 40664961Read ↗

The kinetic landscape of human transcription factorsSemantic proximity Read ↗

Identification of molecular determinants of gene-specific bursting patterns by high-throughput imaging screensSemantic proximity Read ↗

Epigenomic states contribute to coordinated allelic transcriptional bursting in iPSC reprogramming.Semantic proximity Read ↗

Zooming in on single active genes in living mammalian cells.Semantic proximity Read ↗

Transcription factors modulate c-Fos transcriptional bursts.Semantic proximity Read ↗

Chromatin states contribute to coordinated allelic transcriptional bursting to drive iPSC reprogrammingSemantic proximity Read ↗

A comparative analysis across species of maternal mRNA regulation in embryos using QUANTASemantic proximity Read ↗

Single-allele analysis of transcription kinetics in living mammalian cells.Semantic proximity Read ↗

Transcriptional coregulation <i>in cis</i> around a contact insulation site revealed by single-molecule microscopySemantic proximity Read ↗

Protocol for measuring endocrine disruptive effects on transcriptional bursting using single-molecule imaging in human breast cancer cellsSemantic proximity Read ↗

Transcriptional burst kinetics are linked to short term transcriptional memorySemantic proximity Read ↗

A mechanism for robust circadian timekeeping via stoichiometric balance.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.