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Article

A mechanism for robust circadian timekeeping via stoichiometric balance.

Molecular systems biology - 1 Jan 2012

Kim Jae Kyoung, Forger Daniel B

Abstract excerpt

Circadian (∼24 h) timekeeping is essential for the lives of many organisms. To understand the biochemical mechanisms of this timekeeping, we have developed a detailed mathematical model of the mammalian circadian clock. Our model can accurately predict diverse experimental data including the phenotypes of mutations or knockdown of clock genes as well as the time courses and relative expression of clock...

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Identifiers

PMID: 23212247
DOI: 10.1038/msb.2012.62
PMCID: PMC3542529

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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