Article

Chromatin states contribute to coordinated allelic transcriptional bursting to drive iPSC reprogramming

2023-07-13

Abstract excerpt

Molecular mechanisms behind the reprogramming of somatic cells to induced pluripotent stem cells (iPSC) remain poorly understood. While dynamic changes in gene expression are considered to drive reprogramming, the contribution of individual alleles of genes to reprogramming remains unexplored. It is thought that two alleles of a gene can transcribe independently or coordinatedly, which in turn can lead to temporal...

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Literature Corpus work: 71e52d13-08c1-5c57-9b50-aef80fb69b15
DOI: 10.1101/2023.07.13.548864

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