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Article

Intersectin and endophilin condensates prime synaptic vesicles for release site replenishment.

Nature neuroscience - 1 Aug 2025

Ogunmowo Tyler H, Hoffmann Christian, Patel Chintan, Pepper Renee, Wang Han, Gowrisankaran Sindhuja, Idel Johanna, Ho Annie, Raychaudhuri Sumana, Maher Brady J, Cooper Benjamin H, Milosevic Ira, Milovanovic Dragomir, Watanabe Shigeki

Abstract excerpt

Following synaptic vesicle fusion, vacated release sites are replenished immediately by new vesicles for subsequent neurotransmission. These replacement vesicles are assumed to be located near release sites and used by chance. Here we find in mouse hippocampal excitatory synapses that replacement vesicles are clustered near the active zone where release sites reside by intersectin-1. Specifically, intersectin-1...

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Topics

Animals
Synaptic Vesicles
Mice
Hippocampus
Adaptor Proteins, Vesicular Transport

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Synapses

Neurons

Adaptor Proteins, Signal Transducing

Synaptic Transmission

Mice, Inbred C57BL

Mutation

Source

Open in PubMed Open full text

Identifiers

PMID: 40629141
DOI: 10.1038/s41593-025-02002-4
PMCID: PMC12321584

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