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Article

Autophagy-dependent filopodial kinetics restrict synaptic partner choice during Drosophila brain wiring

12 Mar 2020

Abstract excerpt

Brain wiring is remarkably precise, yet most neurons readily form synapses with incorrect partners when given the opportunity. Dynamic axon-dendritic positioning can restrict synaptogenic encounters, but the spatiotemporal interaction kinetics and their regulation remain essentially unknown inside developing brains. Here we show that the kinetics of axonal filopodia restrict synapse formation and partner choice...

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PMID: 32165611
DOI: 10.1038/s41467-020-14781-4

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