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Therapy-Induced Evolution of Human Lung Cancer Revealed by Single-Cell RNA Sequencing

20 Aug 2020

Abstract excerpt

Lung cancer, the leading cause of cancer mortality, exhibits heterogeneity that enables adaptability, limits therapeutic success, and remains incompletely understood. Single-cell RNA sequencing (scRNA-seq) of metastatic lung cancer was performed using 49 clinical biopsies obtained from 30 patients before and during targeted therapy. Over 20,000 cancer and tumor microenvironment (TME) single-cell profiles exposed...

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PMID: 32822576
DOI: 10.1016/j.cell.2020.07.017

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