Article

Function-associated scRNA-seq on single lung cancer organoids unravels the immune landscape of tumor parenchyma

2023-12-12

Abstract excerpt

In vitro models coupled with multimodal approaches are urgently needed to decipher the local tumor immune microenvironment (TIME) owing to the heterogeneous nature of immune cells and their diverse spatial distributions. Here we generate primary lung cancer organoids (pLCOs) by isolating the tumor cell clusters, including the infiltrated immune cells, from dissected lung cancer samples. A FascRNA-seq platform allo...

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Literature Corpus work: cf04f553-3c76-577e-a82c-8808cf569c7a
DOI: 10.1101/2023.12.11.571047

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