Article

Multimodal single-cell profiling of T cell specificity and reactivity in lung cancer

2023-10-06

Abstract excerpt

<h4>SUMMARY</h4> Adoptive transfer of autologous tumor-infiltrating lymphocyte T cells (TILs) offers one of the most promising approaches for cancer immunotherapy. However, high variability in patient responses highlight the need for an enhanced understanding of the transcriptional phenotypes of TILs and reactivity of their T cell receptors (TCR). Here, we employ single-cell multiomics approaches and TCR function...

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Literature Corpus work: d06eb295-4bd2-515f-8e72-2caa6fe7ba55
DOI: 10.1101/2023.10.04.560863

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