Article
Genomic and immune heterogeneity of multiple synchronous lung adenocarcinoma at different developmental stages.
Nature communications - 10 Sept 2024
Zhao Yue, Gao Jian, Wang Jun, Fan Fanfan, Cheng Chao, Qian Danwen, Guo Ran, Zhang Yang, Ye Ting, Augustine Marcellus, Lin Yicong, Shang Jun, Li Hang, Pan Yunjian, Huang Qingyuan, Chen Haiqing, Han Han, Gao Zhendong, Wang Qiming, Zhang Shiyue, Zhang Mou, Fu Fangqiu, Yan Yueren, Fernandez Patel Shanila, Vendramin Roberto, Yuan Hui, Zhang Yawei, Xiang Jiaqing, Hu Hong, Sun Yihua, Li Yuan, Litchfield Kevin, Cao Zhiwei, Chen Haiquan
Abstract excerpt
Multiple synchronous lung cancers (MSLCs) constitute a unique subtype of lung cancer. To explore the genomic and immune heterogeneity across different pathological stages of MSLCs, we analyse 16 MSLCs from 8 patients using single-cell RNA-seq, single-cell TCR sequencing, and bulk whole-exome sequencing. Our investigation indicates clonally independent tumours with convergent evolution driven by shared driver...
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