Geospatial immune variability illuminates differential evolution of lung adenocarcinoma.

doi:10.1038/s41591-020-0900-x

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Article

Geospatial immune variability illuminates differential evolution of lung adenocarcinoma.

Nature medicine - 1 Jul 2020

AbdulJabbar Khalid, Raza Shan E Ahmed, Rosenthal Rachel, Jamal-Hanjani Mariam, Veeriah Selvaraju, Akarca Ayse, Lund Tom, Moore David A, Salgado Roberto, Al Bakir Maise, Zapata Luis, Hiley Crispin T, Officer Leah, Sereno Marco, Smith Claire Rachel, Loi Sherene, Hackshaw Allan, Marafioti Teresa, Quezada Sergio A, McGranahan Nicholas, Le Quesne John, Swanton Charles, Yuan Yinyin

Abstract excerpt

Remarkable progress in molecular analyses has improved our understanding of the evolution of cancer cells toward immune escape1-5. However, the spatial configurations of immune and stromal cells, which may shed light on the evolution of immune escape across tumor geographical locations, remain unaddressed. We integrated multiregion exome and RNA-sequencing (RNA-seq) data with spatial histology mapped by deep...

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Identifiers

PMID: 32461698
DOI: 10.1038/s41591-020-0900-x
PMCID: PMC7610840

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

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