Article

Genomic and immune heterogeneity of multiple synchronous lung adenocarcinoma at different developmental stages

2023-09-29

Abstract excerpt

<title>Abstract</title> <p>Multiple synchronous lung cancers (MSLCs) constitute a unique subtype of lung cancer. To explore the genomic and immune heterogeneity across different pathological stages of MSLCs, we analyzed 16 MSLCs from 8 patients using single-cell RNA-seq, single-cell TCR sequencing, and bulk whole-exome sequencing. Our investigation revealed clonally independent tumors with convergent evolution dr...

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Literature Corpus work: b08572a9-f689-5d56-b9a7-46c025f89057
DOI: 10.21203/rs.3.rs-3272278/v1

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