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Alternative polyadenylation transcriptome-wide association study identifies APA-linked susceptibility genes in brain disorders

3 Feb 2023

Abstract excerpt

Alternative polyadenylation (APA) plays an essential role in brain development; however, current transcriptome-wide association studies (TWAS) largely overlook APA in nominating susceptibility genes. Here, we performed a 3' untranslated region (3'UTR) APA TWAS (3'aTWAS) for 11 brain disorders by combining their genome-wide association studies data with 17,300 RNA-seq samples across 2,937 individuals. We...

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PMID: 36737438
DOI: 10.1038/s41467-023-36311-8

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