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Article

DrFARM: identification of pleiotropic genetic variants in genome-wide association studies.

Nature communications - 1 Jul 2025

Chan Lap Sum, Li Gen, Fauman Eric B, Yin Xianyong, Laakso Markku, Boehnke Michael, Song Peter X K

Abstract excerpt

In a standard analysis, pleiotropic variants are identified by running separate genome-wide association studies (GWAS) and combining results across traits. But such statistical approach based on marginal summary statistics may lead to spurious results. We propose a new statistical approach, Debiased-regularized Factor Analysis Regression Model (DrFARM), through a joint regression model for simultaneous analysis...

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Identifiers

PMID: 40593511
DOI: 10.1038/s41467-025-60439-4
PMCID: PMC12216935

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