Article
PhenoSpD: an integrated toolkit for phenotypic correlation estimation and multiple testing correction using GWAS summary statistics.
GigaScience - 1 Aug 2018
Zheng Jie, Richardson Tom G, Millard Louise A C, Hemani Gibran, Elsworth Benjamin L, Raistrick Christopher A, Vilhjalmsson Bjarni, Neale Benjamin M, Haycock Philip C, Smith George Davey, Gaunt Tom R
Abstract excerpt
Background: Identifying phenotypic correlations between complex traits and diseases can provide useful etiological insights. Restricted access to much individual-level phenotype data makes it difficult to estimate large-scale phenotypic correlation across the human phenome. Two state-of-the-art methods, metaCCA and LD score regression, provide an alternative approach to estimate phenotypic correlation using only...
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