DrFARM: Identification and inference for pleiotropic gene in GWAS

Abstract excerpt

In a standard analysis, pleiotropic variants are identified by running separate genome-wide association studies (GWAS) and combining results across traits. But such two-stage statistical approach may lead to spurious results. We propose a new statistical approach, D ebiased- r egularized F actor A nalysis R egression M odel (DrFARM), through a joint regression model for simultaneous analysis of high-dimensio...

Topics

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• Computer Simulation
• Genetic Pleiotropy
• Genetic Variation
• Genome-Wide Association Study
• Metabolic Syndrome
• Models, Genetic
• Polymorphism, Single Nucleotide
• Regression Analysis

Identifiers and source

Literature Corpus work

b649f2e1-c048-5652-8333-41c3866ca7a1

DOI

10.1101/2022.11.10.515671