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The RNA Binding Protein Bcas2 is Required for Antibody Class Switch in Activated‐B Cells

16 Feb 2025

Abstract excerpt

ABSTRACT In children, hyper‐IgM syndrome type 1 (HIGM1) is a type of severe antibody disorder, the pathogenesis of which remains unclear. The antibody diversity is partially determined by the alternative splicing (AS) in the germline, which is mainly regulated by RNA‐binding proteins, including Breast cancer amplified sequence 2 (Bcas2). However, the effect of Bcas2 on AS and antibody production in activated B...

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PMID: 40585763
DOI: 10.1002/exp.70015

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