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Immunoglobulin class‐switch recombination: Mechanism, regulation, and related diseases

1 Aug 2024

Abstract excerpt

Maturation of the secondary antibody repertoire requires class-switch recombination (CSR), which switches IgM to other immunoglobulins (Igs), and somatic hypermutation, which promotes the production of high-affinity antibodies. Following immune response or infection within the body, activation of T cell-dependent and T cell-independent antigens triggers the activation of activation-induced cytidine deaminase,...

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PMID: 39144468
DOI: 10.1002/mco2.662

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