Article

Targetable genetic alterations of <i>TCF4</i> (E2-2) drive immunoglobulin expression in the activated B-cell subtype of diffuse large B-cell lymphoma

2017-07-31

Abstract excerpt

<h4>ABSTRACT</h4> The activated B-cell (ABC) subtype of diffuse large B-cell lymphoma (DLBCL) is characterized by the chronic activation of signaling initiated by immunoglobulin-μ (IgM). By analyzing DNA copy profiles of 1,000 DLBCLs, we identified gains of 18q21.2 as the most frequent genetic alteration in ABC-like DLBCL. We show that these alterations target the TCF4 (E2-2) transcription factor, and that over-...

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Literature Corpus work: eb375d47-4c37-51c4-9475-702288c03b1f
DOI: 10.1101/170605

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