Article

Non-coding Class Switch Recombination-related transcription in human normal and pathological immune responses

2018-08-03

Abstract excerpt

<h4>Background</h4> Antibody class switch recombination (CSR) to IgG, IgA or IgE is a hallmark of adaptive immunity, allowing antibody function diversification beyond IgM. CSR involves a deletion of the IgM/IgD constant region genes placing a new acceptor Constant (C H ) gene, downstream of the VDJ H exon. CSR depends on non-coding (CSRnc) transcription of donor Iμ and acceptor I H exons, located 5’ upstream o...

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Literature Corpus work: 376fffa9-25d1-5cc2-83d1-ab24984620dd
DOI: 10.1101/384172

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