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Article

Strain background interacts with chromosome 7 aneuploidy to determine commensal and virulence phenotypes in Candida albicans.

PLoS genetics - 1 Jun 2025

Mishra Abhishek, Solis Norma V, Dietz Siobhan M, Crouch Audra L, Filler Scott G, Anderson Matthew Z

Abstract excerpt

The human fungal pathobiont Candida albicans displays extensive genomic plasticity, including large-scale chromosomal changes such as aneuploidy. Chromosome trisomy appears frequently in natural and laboratory strains of C. albicans. Trisomy of specific chromosomes has been linked to large phenotypic effects, such as increased murine gut colonization by strains trisomic for chromosome 7 (Chr7). However, studies...

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PMID: 40577316
DOI: 10.1371/journal.pgen.1011650
PMCID: PMC12204564

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NRG1

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