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Article

Aneuploidy confers a unique transcriptional and phenotypic profile to Candida albicans.

Nature communications - 6 Apr 2025

Mackey Anna I, Fillinger Robert J, Hendricks P Shane, Thomson Gregory J, Cuomo Christina A, Bennett Richard J, Anderson Matthew Z

Abstract excerpt

Inaccurate chromosome segregation can lead to the formation of aneuploid cells that harbor an imbalanced complement of chromosomes. Several fungal species are not only able to tolerate the detrimental effects of aneuploidy but can use it to adapt to environmental pressures. The fungal pathobiont Candida albicans frequently acquires supernumerary chromosomes that enable growth in the presence of antifungal drugs...

Read the complete abstract on PubMed

Topics

Candida albicans
Aneuploidy
Oxidative Stress
Reactive Oxygen Species
Gene Expression Regulation, Fungal
Phenotype

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Transcription, Genetic

Chromosomes, Fungal

Gene Dosage

Fungal Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 40189588
DOI: 10.1038/s41467-025-58457-3
PMCID: PMC11973194

Provenance

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