Back to search

Article

Strain background interacts with chromosome 7 aneuploidy to determine commensal and virulence phenotypes in <i>Candida albicans</i>

2025-01-24

Abstract excerpt

<h4>ABSTRACT</h4> The human fungal pathobiont Candida albicans displays extensive genomic plasticity, including large-scale chromosomal changes such as aneuploidy. Chromosome trisomy appears frequently in natural and laboratory strains of C. albicans . Trisomy of specific chromosomes has been linked to large phenotypic effects, such as increased murine gut colonization by strains trisomic for chromosome 7 (Chr...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
c3b2e209-cf5e-5762-b99d-67e85a3e6ad7
DOI
10.1101/2025.01.23.634449
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Strain background interacts with chromosome 7 aneuploidy to determine commensal and virulence phenotypes in <i>Candida albicans</i>DOI 10.1101/2025.01.23.634449
Strain background interacts with chromosome 7 aneuploidy to determine commensal and virulence phenotypes in Candida albicansSemantic proximity
Aneuploidy and gene dosage regulate filamentation and host colonization by Candida albicansSemantic proximity
A Global Analysis of Mutations Accompanying Microevolution in the Heterozygous Diploid Pathogen <i>Candida albicans</i>Semantic proximity
Global analysis of mutations driving microevolution of a heterozygous diploid fungal pathogen.Semantic proximity
Exposure to the oral host niche yields rapid phenotypic and genotypic diversification in <i>Candida albicans</i>Semantic proximity
Comparative genome hybridization reveals widespread aneuploidy in <i>Candida albicans</i> laboratory strainsSemantic proximity
Aneuploidy promotes transient stress adaptation and metabolic flexibility in the human fungal pathogen <i>Aspergillus fumigatus</i>Semantic proximity
Blood cultures contain populations of genetically diverse <i>Candida albicans</i> strains that may differ in echinocandin tolerance and virulenceSemantic proximity
Host association induces genome changes in <i>Candida albicans</i> which alters its virulenceSemantic proximity
Host-Induced Genome Instability Rapidly Generates Phenotypic Variation across Candida albicans Strains and Ploidy States.Semantic proximity
Genome plasticity in Candida albicans: A cutting-edge strategy for evolution, adaptation, and survivalSemantic proximity
Human commensal <i>Candida albicans</i> strains demonstrate substantial within-host diversity and retained pathogenic potentialSemantic proximity
Select a neighboring publication to make it the new centre.