Article
Global analysis of mutations driving microevolution of a heterozygous diploid fungal pathogen.
Proceedings of the National Academy of Sciences of the United States of America - 11 Sept 2018
Ene Iuliana V, Farrer Rhys A, Hirakawa Matthew P, Agwamba Kennedy, Cuomo Christina A, Bennett Richard J
Abstract excerpt
Candida albicans is a heterozygous diploid yeast that is a commensal of the human gastrointestinal tract and a prevalent opportunistic pathogen. Here, whole-genome sequencing was performed on multiple C. albicans isolates passaged both in vitro and in vivo to characterize the complete spectrum of mutations arising in laboratory culture and in the mammalian host. We establish that, independent of culture niche,...
Topics
- Candida albicans
- Candidiasis
- Chromosomes, Fungal
- Diploidy
- Evolution, Molecular
- Genome, Fungal
- Heterozygote
- Humans
- Loss of Heterozygosity
- Mutation
- Selection, Genetic