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Comparative genome hybridization reveals widespread aneuploidy in <i>Candida albicans</i> laboratory strains

4 Feb 2005

Abstract excerpt

Clinical strains of Candida albicans are highly tolerant of aneuploidies and other genome rearrangements. We have used comparative genome hybridization (CGH), in an array format, to analyse the copy number of over 6000 open reading frames (ORFs) in the genomic DNA of C. albicans laboratory strains carrying one (CAI-4) to three (BWP17) auxotrophies. We find that during disruption of the HIS1 locus all genes...

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PMID: 15720560
DOI: 10.1111/j.1365-2958.2005.04492.x

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