Article
Rapid Phenotypic and Genotypic Diversification After Exposure to the Oral Host Niche in Candida albicans.
Genetics - 1 Jul 2018
Forche Anja, Cromie Gareth, Gerstein Aleeza C, Solis Norma V, Pisithkul Tippapha, Srifa Waracharee, Jeffery Eric, Abbey Darren, Filler Scott G, Dudley Aimée M, Berman Judith
Abstract excerpt
In vitro studies suggest that stress may generate random standing variation and that different cellular and ploidy states may evolve more rapidly under stress. Yet this idea has not been tested with pathogenic fungi growing within their host niche in vivo Here, we analyzed the generation of both genotypic and phenotypic diversity during exposure of Candida albicans to the mouse oral cavity. Ploidy, aneuploidy,...
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