Expression of K1 Toxin Derivatives in Saccharomyces cerevisiae Mimics Treatment with Exogenous Toxin and Provides a Useful Tool for Elucidating K1 Mechanisms of Action and Immunity.

doi:10.3390/toxins9110345

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Article

Expression of K1 Toxin Derivatives in Saccharomyces cerevisiae Mimics Treatment with Exogenous Toxin and Provides a Useful Tool for Elucidating K1 Mechanisms of Action and Immunity.

Toxins - 27 Oct 2017

Gier Stefanie, Schmitt Manfred J, Breinig Frank

Abstract excerpt

Killer toxin K1 is a heterodimeric protein toxin secreted by Saccharomyces cerevisiae strains infected with the M1 double-stranded RNA 'killer' virus. After binding to a primary receptor at the level of the cell wall, K1 interacts with its secondary plasma membrane receptor Kre1p, eventually leading to an ionophoric disruption of membrane function. Although it has been under investigation for decades, neither the...

Topics

Killer Factors, Yeast
Phenotype
Receptors, Cell Surface
Saccharomyces cerevisiae

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PMID: 29076990
DOI: 10.3390/toxins9110345
PMCID: PMC5705960

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