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Article

A Saccharomyces cerevisiae genome-wide mutant screen for altered sensitivity to K1 killer toxin.

Genetics - 1 Mar 2003

Pagé Nicolas, Gérard-Vincent Manon, Ménard Patrice, Beaulieu Maude, Azuma Masayuki, Dijkgraaf Gerrit J P, Li Huijuan, Marcoux José, Nguyen Thuy, Dowse Tim, Sdicu Anne-Marie, Bussey Howard

Abstract excerpt

Using the set of Saccharomyces cerevisiae mutants individually deleted for 5718 yeast genes, we screened for altered sensitivity to the antifungal protein, K1 killer toxin, that binds to a cell wall beta-glucan receptor and subsequently forms lethal pores in the plasma membrane. Mutations in 268 genes, including 42 in genes of unknown function, had a phenotype, often mild, with 186 showing resistance and 82...

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PMID: 12663529
DOI: 10.1093/genetics/163.3.875
PMCID: PMC1462477

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