Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Analysis of Yeast Killer Toxin K1 Precursor Processing via Site-Directed Mutagenesis: Implications for Toxicity and Immunity.

mSphere - 12 Feb 2020

Gier Stefanie, Schmitt Manfred J, Breinig Frank

Abstract excerpt

K1 represents a heterodimeric A/B toxin secreted by virus-infected Saccharomyces cerevisiae strains. In a two-staged receptor-mediated process, the ionophoric activity of K1 leads to an uncontrolled influx of protons, culminating in the breakdown of the cellular transmembrane potential of sensitive cells. K1 killer yeast necessitate not only an immunity mechanism saving the toxin-producing cell from its own toxin...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Membrane
Share to Killer Factors, Yeast
Share to Mutagenesis, Site-Directed

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Phenotype

Share to RNA Viruses

Share to Saccharomyces cerevisiae

Share to Saccharomyces cerevisiae Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 32051241
DOI: 10.1128/mSphere.00979-19
PMCID: PMC7021474

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Analysis of Yeast Killer Toxin K1 Precursor Processing via Site-Directed Mutagenesis: Implications for Toxicity and Immunity.PMID 32051241Read ↗

Expression of K1 Toxin Derivatives in Saccharomyces cerevisiae Mimics Treatment with Exogenous Toxin and Provides a Useful Tool for Elucidating K1 Mechanisms of Action and Immunity.Semantic proximity Read ↗

Genetic and molecular approaches to synthesis and action of the yeast killer toxin.Semantic proximity Read ↗

Mutational analysis of K28 preprotoxin processing in the yeast Saccharomyces cerevisiae.Semantic proximity Read ↗

Alanine-scanning of the yeast killer toxin K2 reveals key residues for activity, gain-of-function variants, and supports prediction of precursor processing and 3D structureSemantic proximity Read ↗

Yeast killer toxin K1 and its exploitation in genetic manipulations.Semantic proximity Read ↗

Immunity to killer toxin K1 is connected with the Golgi-to-vacuole protein degradation pathway.Semantic proximity Read ↗

Killer-toxin-resistant kre12 mutants of Saccharomyces cerevisiae: genetic and biochemical evidence for a secondary K1 membrane receptor.Semantic proximity Read ↗

Yeast Viral Killer Toxin K1 Induces Specific Host Cell Adaptions via Intrinsic Selection Pressure.Semantic proximity Read ↗

Role of the gamma component of preprotoxin in expression of the yeast K1 killer phenotype.Semantic proximity Read ↗

A yeast killer toxin screen provides insights into a/b toxin entry, trafficking, and killing mechanisms.Semantic proximity Read ↗

Killer toxin K28 resistance in yeast relies on COG complex-mediated trafficking of the defence factor Ktd1.Semantic proximity Read ↗

A Saccharomyces cerevisiae genome-wide mutant screen for altered sensitivity to K1 killer toxin.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.