Article

Functional dissection of Leishmania major membrane components in resistance to cholesterol-dependent cytolysins

2025-12-16

Abstract excerpt

<h4>ABSTRACT</h4> Bacteria use cholesterol-dependent cytolysins (CDCs) to damage eukaryotes. While well-studied in mammals, the mechanisms by which CDCs bind to and kill protozoans remains unclear. CDCs bind to the human pathogen Leishmania major , but only kill in the absence of sphingolipids. The contribution of other leishmanial membrane components to CDC binding and cytotoxicity remains unknown. Here, we use...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: c93baa4d-cc08-5b29-b1be-068c09645f57
DOI: 10.64898/2025.12.12.693994

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Functional dissection of Leishmania major membrane components in resistance to cholesterol-dependent cytolysinsDOI 10.64898/2025.12.12.693994Read

Sphingolipids protect ergosterol in the <i>Leishmania major</i> membrane from sterol-specific toxinsSemantic proximity Read

Distant relatives of a eukaryotic cell-specific toxin family evolved a complement-like mechanism to kill bacteriaSemantic proximity Read

Perfringolysin O structure and mechanism of pore formation as a paradigm for cholesterol-dependent cytolysins.Semantic proximity Read

Interaction of Macrophages and Cholesterol-Dependent Cytolysins: The Impact on Immune Response and Cellular SurvivalSemantic proximity Read

A Key Motif in the Cholesterol-Dependent Cytolysins Reveals a Large Family of Related ProteinsSemantic proximity Read

Structural basis for tuning activity and membrane specificity of bacterial cytolysins.Semantic proximity Read

Cellular internalization of cytolethal distending toxin: a new end to a known pathway.Semantic proximity Read

Cytolethal Distending Toxin Family Members Are Differentially Affected by Alterations in Host Glycans and Membrane CholesterolSemantic proximity Read

Characterization of Tigurilysin, a Novel Human CD59-Specific Cholesterol-Dependent Cytolysin, Reveals a Role for Host Specificity in Augmenting Toxin ActivitySemantic proximity Read

The cholesterol-dependent cytolysin pneumolysin from Streptococcus pneumoniae binds to lipid raft microdomains in human corneal epithelial cells.Semantic proximity Read

Identification and Characterization of the First Cholesterol-Dependent Cytolysins from Gram-Negative BacteriaSemantic proximity Read

Pneumolysin: Pathogenesis and Therapeutic TargetSemantic proximity Read