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Article

CARD11 signaling regulates CD8+ T cell tumoricidal function.

Nature immunology - 1 Jul 2025

Hu Yu, Zhao Qifan, Qin Yingquan, Mei Song, Wang Benyu, Zhou Haoyue, Han Linli, Zang Yi, Yao Liangjiao, He Zhe, Li Yingyi, Li Hecheng, Zhang Peng, Zhang Yan, Lenardo Michael J, Lu Wei

Abstract excerpt

Chronic stimulation in the tumor microenvironment can induce exhausted CD8+ T (Tex) cells that have limited tumoricidal activity. Here, we show an inverse correlation between signal strength and Tex cell differentiation by using patient-derived mutations in the T cell receptor (TCR)-signaling protein CARD11. Strong TCR signaling of the E134G mutant inhibits Tex cell differentiation and increases tumor growth....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 40533509
DOI: 10.1038/s41590-025-02192-w

Genes

CARD11

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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