Article

PD-1 blockade-driven anti-tumor CD8 <sup>+</sup> T cell immunity requires XCR1 <sup>+</sup> dendritic cells

2020-04-30

Abstract excerpt

CD8 + T cells are required for effective anti-PD-1 (αPD-1) cancer immunotherapy. Type 1 conventional dendritic cells (cDC1s) bearing XCR1 critically mediate the initiation of protective anti-tumor CD8 + T cell responses in mice and humans. However, whether cDC1s contribute to evoking the effector function of CD8 + T cells during αPD-1 antibody therapy remains unclear. Here, by deleting cDC1s at the effector pha...

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Literature Corpus work: 0662acab-08d7-5ff4-820a-4a8f465047c6
DOI: 10.1101/2020.04.28.066639

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PD-1 blockade-driven anti-tumor CD8 <sup>+</sup> T cell immunity requires XCR1 <sup>+</sup> dendritic cellsDOI 10.1101/2020.04.28.066639Read

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