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Article

CARD11 gain-of-function mutation drives cell-autonomous accumulation of PD-1+ ICOShigh activated T cells, T-follicular, T-regulatory and T-follicular regulatory cells.

Frontiers in immunology - 1 Jan 2023

Masle-Farquhar Etienne, Jeelall Yogesh, White Jacqueline, Bier Julia, Deenick Elissa K, Brink Robert, Horikawa Keisuke, Goodnow Christopher Carl

Abstract excerpt

Introduction: Germline CARD11 gain-of-function (GOF) mutations cause B cell Expansion with NF-κB and T cell Anergy (BENTA) disease, whilst somatic GOF CARD11 mutations recur in diffuse large B cell lymphoma (DLBCL) and in up to 30% of the peripheral T cell lymphomas (PTCL) adult T cell leukemia/lymphoma (ATL), cutaneous T cell lymphoma (CTCL) and Sezary Syndrome. Despite their frequent acquisition by PTCL, the T...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 36960072
DOI: 10.3389/fimmu.2023.1095257
PMCID: PMC10028194

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