Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

CARD11 regulates the thymic Treg development in an NF-κB-independent manner.

Frontiers in immunology - 1 Jan 2024

Hu Yu, Han Lingli, Xu Wenwen, Li Tianci, Zhao Qifan, Lu Wei, Sun Jinqiao, Wang Ying

Abstract excerpt

Introduction: CARD11 is a lymphoid lineage-specific scaffold protein regulating the NF-κB activation downstream of the antigen receptor signal pathway. Defective CARD11 function results in abnormal development and differentiation of lymphocytes, especially thymic regulatory T cells (Treg). Method: In this study, we used patients' samples together with transgenic mouse models carrying pathogenic CARD11 mutations...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CARD Signaling Adaptor Proteins
Share to Cell Differentiation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Guanylate Cyclase

Share to Mice, Transgenic

Share to NF-kappa B

Share to Primary Immunodeficiency Diseases

Share to T-Lymphocytes, Regulatory

Share to Thymus Gland

Source

Open in PubMed Open full text

Identifiers

PMID: 38650932
DOI: 10.3389/fimmu.2024.1364957
PMCID: PMC11033321

Genes

CARD11
FOXO1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

CARD11 regulates the thymic Treg development in an NF-κB-independent manner.PMID 38650932Read ↗

CARD11 gain-of-function mutation drives cell-autonomous accumulation of PD-1+ ICOShigh activated T cells, T-follicular, T-regulatory and T-follicular regulatory cells.Semantic proximity Read ↗

Pathway-Specific Defects in T, B, and NK Cells and Age-Dependent Development of High IgE in Mice Heterozygous for a CADINS-Associated Dominant Negative CARD11 Allele.Semantic proximity Read ↗

The effect of CARD11 mutation and HBZ expression accelerated lymphoproliferative diseases and formed the pathological basis for adult T-cell leukemia/lymphomaSemantic proximity Read ↗

Mechanistic impact of oligomer poisoning by dominant-negative CARD11 variantsSemantic proximity Read ↗

The MAGUK family protein CARD11 is essential for lymphocyte activation.Semantic proximity Read ↗

Oncogenic CARD11 mutations induce hyperactive signaling by disrupting autoinhibition by the PKC-responsive inhibitory domain.Semantic proximity Read ↗

Lymphomagenic CARD11/BCL10/MALT1 signaling drives malignant B-cell proliferation via cooperative NF-κB and JNK activation.Semantic proximity Read ↗

Intramolecular Interactions and Regulation of Cofactor Binding by the Four Repressive Elements in the Caspase Recruitment Domain-containing Protein 11 (CARD11) Inhibitory Domain.Semantic proximity Read ↗

An NF-κB Transcription-Factor-Dependent Lineage-Specific Transcriptional Program Promotes Regulatory T Cell Identity and Function.Semantic proximity Read ↗

B-cell lymphocytosis and reprogramming due to biallelic CARD11 mutations.Semantic proximity Read ↗

A quantitative signaling screen identifies CARD11 mutations in the CARD and LATCH domains that induce Bcl10 ubiquitination and human lymphoma cell survival.Semantic proximity Read ↗

Human lymphoma mutations reveal CARD11 as the switch between self-antigen-induced B cell death or proliferation and autoantibody production.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.