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BCL11B targeting in tumor CD8 <sup>+</sup> T cells amplifies anti-tumor response by blocking exhaustion while promoting stemness and cytotoxicity

2026-08-07

Abstract excerpt

<h4>Summary</h4> Tumor infiltrating CD8 + T cells (TILs) progress to a state of terminal exhaustion (Ttex) which have impaired functionality and are nonrenewable. However their precursors (Tpex) are renewable and can generate efficient effector cells. We started from the observation that melanoma patients undergoing therapy with checkpoint inhibitors show increased survival when their T cells have low BCL11B mR...

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Literature Corpus work
4006933f-9ea3-552e-9de4-449a4d787716
DOI
10.64898/2026.08.03.742578
Open publication

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