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Article

Oncogenic CARD11 mutations induce hyperactive signaling by disrupting autoinhibition by the PKC-responsive inhibitory domain.

Biochemistry - 28 Sept 2010

Lamason Rebecca L, McCully Ryan R, Lew Stefanie M, Pomerantz Joel L

Abstract excerpt

The regulated activation of NF-κB by antigen receptor signaling is required for normal B and T lymphocyte activation during the adaptive immune response. Dysregulated NF-κB activation is associated with several types of lymphoma, including diffuse large B cell lymphoma (DLBCL). During normal anti...

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Share to Carcinogens
Share to CARD Signaling Adaptor Proteins
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Lymphocyte Activation

Share to Lymphoma, Large B-Cell, Diffuse

Share to NF-kappa B

Share to Protein Kinase C

Share to Receptors, Antigen

Source

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Identifiers

PMID: 20799731
DOI: 10.1021/bi101052d
PMCID: PMC2943563

Genes

CARD11

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20799731-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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Oncogenic CARD11 mutations induce hyperactive signaling by disrupting autoinhibition by the PKC-responsive inhibitory domain.PMID 20799731Read ↗

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