Article
B-cell lymphocytosis and reprogramming due to biallelic CARD11 mutations.
The Journal of allergy and clinical immunology - 1 May 2026
Bhattad Sagar, Gil Hwi M, Ruchinskas Allison, Stinson Jeffrey R, Staines Boone Aidé Tamara, Mohite Rachna Shanbhag, Janardhanan Jyothi, Singh Neha, Mariskanish Christine, Choi Joseph M, Basaria Shamel, Ye Xiang, Snow Andrew L, Markle Janet G
Abstract excerpt
BACKGROUND: Adaptive immune responses are tightly controlled by proteins including CARD11 that regulate signaling events downstream of the T- and B-cell receptors. Germline mutations in CARD11 cause several distinct monogenic inborn errors of immunity with early childhood onset and potentially fatal prognoses. Somatic CARD11 gain-of-function mutations are associated with B-cell malignancies. Precisely how various...
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