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The Cul5 E3 Ligase Complex Is a Key Negative Feedback Regulator of TCR/IL2 Signaling and Anti-Tumor Activity in CD8 <sup>+</sup> T Cells

2022-11-17

Abstract excerpt

CD8 + T cells play an important role in tumor immune surveillance and control. Better understanding of the regulation of their anti-tumor actions and improving their cytotoxic function and persistence will help advancing cancer immunotherapies. Here, we report the development of a step-wise CRISPR knockout (KO) screening strategy under the selection of TGF-β, a clinically relevant immunosuppressive pressure. The...

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Literature Corpus work: 4c170b4c-4144-5fea-968d-1d33e8fc8490
DOI: 10.1101/2022.11.16.516824

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