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Article

Human lymphoma mutations reveal CARD11 as the switch between self-antigen-induced B cell death or proliferation and autoantibody production.

The Journal of experimental medicine - 22 Oct 2012

Jeelall Yogesh S, Wang James Q, Law Hsei-Di, Domaschenz Heather, Fung Herman K H, Kallies Axel, Nutt Stephen L, Goodnow Christopher C, Horikawa Keisuke

Abstract excerpt

Self-tolerance and immunity are actively acquired in parallel through a poorly understood ability of antigen receptors to switch between signaling death or proliferation of antigen-binding lymphocytes in different contexts. It is not known whether this tolerance-immunity switch requires global rewiring of the signaling apparatus or if it can arise from a single molecular change. By introducing individual CARD11...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 23027925
DOI: 10.1084/jem.20112744
PMCID: PMC3478930

Genes

CARD11

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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