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Article

Mutation in the rat interleukin 34 gene impacts macrophage development, homeostasis, and inflammation.

Life science alliance - 1 Sept 2025

Huang Stephen, Patkar Omkar L, Schulze Sarah, Carter-Cusack Dylan, Millard Susan, Ranpura Ginell, Green Emma K, Maxwell Emma, Kanesarajah Jeeva, Cowin Gary, Stimson Damion, Kurniawan Nyoman D, Keshvari Sahar, Allavena Rachel, Pettit Allison R, Irvine Katharine M, Hume David A

Abstract excerpt

Interleukin 34 (IL34) and colony-stimulating factor 1 (CSF1) signal through a shared receptor (CSF1R) to control macrophage survival, differentiation, and function. Here, we describe the impact of loss-of-function mutation in the rat Il34 gene. In contrast to IL34 mutant mice, macrophages within squamous epithelia (Langerhans cells) were not significantly depleted in Il34 -/- rats. In the brain, microglia and...

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Source

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Identifiers

PMID: 40533345
DOI: 10.26508/lsa.202503264
PMCID: PMC12177736

Genes

IL34
CSF1
CSF1R

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 9 Sept 2026.

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