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Article

Homozygous kinase-dead Csf1r mutation in outbred mice reveals essential and redundant functions of tissue resident macrophages.

Journal of leukocyte biology - 8 Jun 2026

Jacquelin Sebastien, Maxwell Emma, Taylor Isis, Green Emma, O'Brien Conan J O, Jessen Eline E, Ranpura Ginell, Guo Jintao, Nooru-Mohamed Fathima, Liu Yajun, Keshvari Sahar, Huang Stephen, Cooper Emily, Lane Steven W, Flegg Cameron, Kasherman Maria A, Sokolowski Kamil, Pettit Allison R, Hume David A, Irvine Katharine M

Abstract excerpt

The proliferation, differentiation, and survival of cells of the macrophage lineage depends on signals from the macrophage colony-stimulating factor receptor (CSF1R). On a C57BL/6J background homozygous kinase-dead Csf1r mutation (Csf1rE631K/E631K-E631Km/m) causes perinatal lethality. By contrast, E631Km/m mice on a mixed genetic background (C57 × BALB/c) were osteoclast-deficient/osteopetrotic and growth...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 42266149
DOI: 10.1093/jleuko/qiag074

Genes

CSF1R
CSF1
IGF1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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