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Article

Interleukin 1 type 1 receptor restore: a genetic mouse model for studying interleukin 1 receptor-mediated effects in specific cell types.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 18 Feb 2015

Liu Xiaoyu, Yamashita Tetsuji, Chen Qun, Belevych Natalya, Mckim Daniel B, Tarr Andrew J, Coppola Vincenzo, Nath Nikitaa, Nemeth Daniel P, Syed Zunera W, Sheridan John F, Godbout Jonathan P, Zuo Jian, Quan Ning

Abstract excerpt

Interleukin-1 (IL-1) mediates diverse neurophysiological and neuropathological effects in the CNS through type I IL-1 receptor (IL-1R1). However, identification of IL-1R1-expressing cell types and cell-type-specific functions of IL-1R1 remains challenging. In this study, we created a novel genetic mouse model in which IL-1R1 gene expression is disrupted by an intronic insertion of a loxP flanked disruptive...

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Identifiers

PMID: 25698726
DOI: 10.1523/JNEUROSCI.3199-14.2015
PMCID: PMC4331620

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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