Article
Interkeukin‐34, a cytokine crucial for the differentiation and maintenance of tissue resident macrophages and <scp>L</scp>angerhans cells
15 Apr 2014
Abstract excerpt
IL-34 is a recently discovered cytokine that acts on tissue resident macrophages and Langerhans cells upon binding the receptor for CSF-1, CSF-1R. The existence of two ligands for CSF-1R, IL-34, and CSF-1, raises several intriguing questions. Are IL-34 and CSF-1 redundant or does each perform temporally and spatially distinct functions? Is IL-34 involved in human pathology? Would therapeutic strategies based on...
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